CIA Induction Kits - For induction of collagen-induced arthritis (CIA) in DBA/1 mice CIA is induced by chicken or bovine type II collagen in CFA, followed by a type II collagen booster 18 to 21 days later. The collagen booster is usually administered in IFA. Alternatively, the booster can be administered in CFA, resulting in faster CIA development and increased severity. 1. Consistently induce..